Advanced Research & Scale Up Freeze Dryer LyoBeta

Control system
One of the main new features of the LyoBeta Series freeze-dryers is the incorporation of a non-proprietary PLC,
instead of the classic microprocessor, more commonly used in this type of equipment. This system, fully proven
in the industrial models, guarantees maximum reliability and reproducibility in the process, in accordance
with the principles of cGLP.
The system allows control of the freeze-dryer functions via a graphic HMI (Human Machine Interface) user
interface, which offers the following functionality:
• Displaying of information on system elements (valves, motors, indicators, etc.)
• Receiving alarm information
• Modifying the parameters of the freeze-dryer cycle
• Eliminating the possibility of error in operation
• Protecting the system from unauthorized use
• Recipes development
• Download info to USB key
The user interface presents information in an attractive and intelligible manner on a graphical 6,5” color touch
screen, through which different data screens can be accessed by means of touch zones

Precise Control and Temperature Uniformity

The thermal fluid circulates inside the sandwich type channels
of the shelves. This allows product pre-freezing and later heating
during sublimation phase. An additional shelf thermally balances
the equipment. THIS FEATURE FOR LABORATORY FREEZE-
DRYERS GUARANTEES UNIFORM HEAT TRANSFER AT ALL
THE SHELVES.
The LyoBeta has the vacuum sensor in the chamber, for monitoring
and control of the pressure of the product environment. THIS
ENABLES EVALUATION AND ACHIEVEMENT OF THE FINEST
SCALE-UP RESULTS.

Designed thinking on GLP basic research & development

• The unit’s design offers the outstanding performance for technology transfer activities and work in advanced R&D Centres.
• Unit suitable for laboratories: compact unit mounted on casters, easy to install.
• Easy recipe development: quality and adaptation of the temperature sensors (shelf, product and condenser) and vacuum. Temperature, pressure and time control system.
• Recipe optimization capability. Possibility of thermodynamic control and pressure rise test with the isolation valve.
• Reliability of results: temperature uniformity (shelf flatness, high quality components, upper radiation shelf), shelf heating and cooling rates (1 ºC/min), etc.
• Flexible use: high capacity for working with bulk materials, option to attach manifolds. There are also different sizes and types of vials.
• Robustness: laboratory equipment with industrial finish (easy to clean, stainless steel chamber, condenser and plates) and industrial components (sensors, vacuum pump, exchangers, etc.).
• Reliable operation: non-proprietary control system via PLC (Siemens).
• Flexible use: with a touch screen user interface.
• Option to save developed cycles and export data to other platforms (Excel) with the LyoLogger data acquisition software.
• Opportunity to carry out optimization studies for new formulae (scale up), with SCADA LyoLab software, providing extensive documentation for technology transfer (optional).

Optimized technical features

• Easy to scale-up process to industrial freeze-dryers.
• Include as standard options:
  • Isolation valve
  • Stoppering device
  • Air/water cooled
  • Security sensor open/closed door
• Condenser 30 Kg, minimum T -85ºC
• Shelves temperature from -60ºC up to 80ºC
• From 0,45m2 up to 0,9m2 useful shelves area
• Exchangeable distance between shelves
• Fully updated and redesigned control system
• User friendly
• Allows use of a SCADA (Supervisory Control and Data Acquisition) software.
• Easy to locate in final position and can also be moved through standard laboratory doors.

Accessories & Options

• Venting HEPA filter
• Clean room configuration
• Vacuum control system with controlled leak
• Eutectic point monitor
• Capacitance manometer
• SCADA LyoSuiteTM control software.
• LYOMETRICS – sublimation front temperature monitoring
• LYONUC – nucleation software
• End-point detector via residual humidity probe
• Sample thief
• IQ+OQ qualification
• Loading trays
• Spacers for changing distances
• Manifold